eIF4E–4EGI1 Complex (PDB 4TPW)

PDB ID: 4TPW

Method: X-ray diffraction (2.10 Å)

Organism: Homo sapiens

Expression: Escherichia coli

Ligand: 4EGI-1

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eIF4E complex with 4EGI1 (PDB 4TPW)

Structure Summary: PDB 4TPW

PDB ID 4TPW represents the crystal structure of human eIF4E in complex with the small-molecule inhibitor 4EGI-1, which disrupts the eIF4E–eIF4G interaction and modulates translation initiation.

The structure reveals an allosteric inhibition mechanism, distinct from the cap-binding pocket. Resolution: 2.10 Å.

  • Organism: Homo sapiens
  • Expression system: E. coli
  • Method: X-ray diffraction
  • Ligand: 4EGI-1